生物
发病机制
疾病
促炎细胞因子
细胞因子
免疫学
破译
医学
银屑病
遗传学
炎症
病理
作者
Saikat Majumder,Mandy J. McGeachy
出处
期刊:Annual Review of Immunology
[Annual Reviews]
日期:2021-04-26
卷期号:39 (1): 537-556
被引量:26
标识
DOI:10.1146/annurev-immunol-101819-092536
摘要
The IL-17 family is an evolutionarily old cytokine family consisting of six members (IL-17A through IL-17F). IL-17 family cytokines signal through heterodimeric receptors that include the shared IL-17RA subunit, which is widely expressed throughout the body on both hematopoietic and nonhematopoietic cells. The founding family member, IL-17A, is usually referred to as IL-17 and has received the most attention for proinflammatory roles in autoimmune diseases like psoriasis. However, IL-17 is associated with a wide array of diseases with perhaps surprisingly variable pathologies. This review focuses on recent advances in the roles of IL-17 during health and in disease pathogenesis. To decipher the functions of IL-17 in diverse disease processes it is useful to first consider the physiological functions that IL-17 contributes to health. We then discuss how these beneficial functions can be diverted toward pathogenic amplification of deleterious pathways driving chronic disease.
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