生物粘附
乙烯醇
壳聚糖
自愈水凝胶
胶粘剂
共价键
材料科学
化学
化学工程
粘附
高分子化学
药物输送
聚合物
图层(电子)
复合材料
纳米技术
有机化学
工程类
作者
Zejun Dong,Yining Sun,Yuhui Chen,Liu Yan,Chuhua Tang,Xiaozhong Qu
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2019-11-01
卷期号:2 (12): 5985-5994
被引量:30
标识
DOI:10.1021/acsabm.9b00912
摘要
In this work, chitosan (CS) decorated metronidazole (MTZ) microcapsules (CS@MTZ) were synthesized and used as a cross-linker for the preparation of a poly(vinyl alcohol) (PVA) injectable hydrogel by dynamic covalent bonding and ionic interaction through a 4-carboxyphenylboronic acid bridge. The use of MTZ microcapsules efficiently slowed down the release rate of the hydrophilic antibiotic from the hydrogel matrix. Besides, the hydrophobicity of the microcapsules endows the PVA@CS@MTZ hydrogel to be sticky to a substrate in wet conditions, under a suggested mechanism of evicting the water boundary layer on the substrate. The sustained release behavior endowed a prolonged bacteriostasis ability of the hydrogel formulation for up to 14 days in vitro, and the bioadhesive property as well as the injectability of the hydrogel benefited the topical delivery of MTZ in periodontal pockets and exhibited desirable antibacterial capacity in 1 week on the rat periodontitis model.
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