模块化设计
计算机科学
电子线路
逻辑门
可扩展性
计算
DNA运算
合成生物学
生物系统
纳米技术
理论计算机科学
算法
材料科学
计算生物学
工程类
电气工程
生物
操作系统
数据库
作者
Gourab Chatterjee,Neil Dalchau,Richard A. Muscat,Andrew Phillips,Georg Seelig
标识
DOI:10.1038/nnano.2017.127
摘要
Cells use spatial constraints to control and accelerate the flow of information in enzyme cascades and signalling networks. Synthetic silicon-based circuitry similarly relies on spatial constraints to process information. Here, we show that spatial organization can be a similarly powerful design principle for overcoming limitations of speed and modularity in engineered molecular circuits. We create logic gates and signal transmission lines by spatially arranging reactive DNA hairpins on a DNA origami. Signal propagation is demonstrated across transmission lines of different lengths and orientations and logic gates are modularly combined into circuits that establish the universality of our approach. Because reactions preferentially occur between neighbours, identical DNA hairpins can be reused across circuits. Co-localization of circuit elements decreases computation time from hours to minutes compared to circuits with diffusible components. Detailed computational models enable predictive circuit design. We anticipate our approach will motivate using spatial constraints for future molecular control circuit designs. Fast and scalable molecular logic circuits can be created through the spatial organization of DNA hairpins on DNA origami scaffolds.
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