透皮
角质层
药物输送
真皮
医学
激素
药理学
药品
从长凳到床边
化学
纳米技术
材料科学
病理
内科学
医学物理学
作者
Thuy Trang Nguyen,Thi Thuy Dung Nguyen,Nguyen‐Minh‐An Tran,Vo Van Giau
标识
DOI:10.1016/j.biopha.2021.112393
摘要
The skin is recognized as a potential target for local and systemic drug delivery and hormone. However, the transdermal route of drug administration seems to be limited by substantial barrier properties of the skin. Recently, delivering hormone via the skin by transdermal patches is a big challenge because of the presence of the stratum corneum that prevents the application of hormone via this route. In order to overcome the limitations, microneedle (MN), consisting of micro-sized needles, are a promising approach to drill the stratum corneum and release hormone into the dermis via a minimal-invasive route. This review aimed to highlight advances in research on the development of MNs-based therapeutics for their implications in hormone delivery. The challenges during clinical translation of MNs from bench to bedside are also discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI