神经科学
体感系统
脑干
脊髓
神经元
神经发生
生物
运动神经元
背
解剖
作者
Shan Meltzer,Celine Santiago,Nikhil Sharma,David D. Ginty
出处
期刊:Neuron
[Elsevier]
日期:2021-12-01
卷期号:109 (23): 3736-3757
被引量:46
标识
DOI:10.1016/j.neuron.2021.09.004
摘要
Primary somatosensory neurons convey salient information about our external environment and internal state to the CNS, allowing us to detect, perceive, and react to a wide range of innocuous and noxious stimuli. Pseudo-unipolar in shape, and among the largest (longest) cells of most mammals, dorsal root ganglia (DRG) somatosensory neurons have peripheral axons that extend into skin, muscle, viscera, or bone and central axons that innervate the spinal cord and brainstem, where they synaptically engage the central somatosensory circuitry. Here, we review the diversity of mammalian DRG neuron subtypes and the intrinsic and extrinsic mechanisms that control their development. We describe classical and contemporary advances that frame our understanding of DRG neurogenesis, transcriptional specification of DRG neurons, and the establishment of morphological, physiological, and synaptic diversification across somatosensory neuron subtypes.
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