ToxAnalyzer: A user-friendly web tool for interactive data analysis and visualization of chemical compounds from the Comparative Toxicogenomics Database (CTD)™

Toxicology is a field of science that has undergone changes in recent years. Using modern sequencing technologies, it went from an exclusive animal-based science to a field of data-based decision making. Many databases store important data about toxicology experiments, which can be useful to understand the mechanisms concerning chemical product toxicity. One of these databases is the “Comparative Toxicogenomics Database” (CTD) that provides information about diseases, genes, compounds, and their role in toxicity. However, a simple search in CTD produces a high volume of data to be manually and individually analyzed. Most tools available to analyze CTD’s data require previous installation and the knowledge of writing and manipulating programming scripts. Here, we show ToxAnalyzer, a web tool that provides an organized overview of the complete compound data available in CTD to aid users in possible toxicogenomic studies. Our application withdraws data from CTD’s servers and uses a set of Python scripts to process and display important information about any chemical compound found in CTD. Using the chemical name, a user can gather information about related publications, associated organisms, gene interactions, and other relative plots. If users need more information about an interaction between a specific gene and a chemical compound, PubMed ID links are available to access the original publications. Therefore, ToxAnalyzer is user-friendly and can be accessed with any device with internet access, requiring absolutely no programming knowledge. ToxAnalyzer is available at https://tox-analyzer.com/.