瞬时受体电位通道
细胞生物学
TRPV公司
磷脂酰肌醇
化学
受体
生物
TRPV1型
激酶
生物化学
作者
Itaru Kojima,Mitsuru Nagasawa
出处
期刊:Handbook of experimental pharmacology
日期:2014-01-01
卷期号:: 247-272
被引量:45
标识
DOI:10.1007/978-3-642-54215-2_10
摘要
Transient receptor potential vanilloid type 2, TRPV2, is a calcium-permeable cation channel belonging to the TRPV channel family. This channel is activated by heat (>52 °C), various ligands, and mechanical stresses. In most of the cells, a large portion of TRPV2 is located in the endoplasmic reticulum under unstimulated conditions. Upon stimulation of the cells with phosphatidylinositol 3-kinase-activating ligands, TRPV2 is translocated to the plasma membrane and functions as a cation channel. Mechanical stress may also induce translocation of TRPV2 to the plasma membrane. The expression of TRPV2 is high in some types of cells including neurons, neuroendocrine cells, immune cells involved in innate immunity, and certain types of cancer cells. TRPV2 may modulate various cellular functions in these cells.
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