医学
炎症性肠病
流行病学
人口
梅德林
疾病
儿科
人口学
溃疡性结肠炎
入射(几何)
内科学
环境卫生
社会学
法学
物理
光学
政治学
作者
M Ellen Kuenzig,Stephen Fung,Luba Marderfeld,Joyce Wing-Yan Mak,Gilaad G. Kaplan,Siew C. Ng,David C. Wilson,Fiona Cameron,Paul Henderson,Paulo Gustavo Kotze,Jasmine Bhatti,Vixey Fang,Samantha Gerber,Evelyne Guay,Supun Kotteduwa Jayawarden,Leo Kadota,Fernando Maldonado D,Jessica Amankwah Osei,Ryan Sandarage,Amanda Stanton,Melissa Wan,Eric I Benchimol
出处
期刊:Gastroenterology
[Elsevier]
日期:2022-04-01
卷期号:162 (4): 1147-1159.e4
被引量:192
标识
DOI:10.1053/j.gastro.2021.12.282
摘要
Background & aims
The incidence of inflammatory bowel disease (IBD) is increasing internationally, particularly in nations with historically low rates. Previous reports of the epidemiology of pediatric-onset IBD identified a paucity of data. We systematically reviewed the global trends in incidence and prevalence of IBD diagnosed in individuals <21 years old over the first 2 decades of the 21st century. Methods
We systematically reviewed studies indexed in MEDLINE, EMBASE, Airiti Library, and SciELO from January 2010 to February 2020 to identify population-based studies reporting the incidence and/or prevalence of IBD, Crohn's disease, ulcerative colitis, and/or IBD-unclassified. Data from studies published before 2000 were derived from a previously published systematic review. We described the geographic distribution and trends in children of all ages and limiting to very early onset (VEO) IBD. Results
A total of 131 studies from 48 countries were included. The incidence and prevalence of pediatric-onset IBD is highest in Northern Europe and North America and lowest in Southern Europe, Asia, and the Middle East. Among studies evaluating trends over time, most (31 of 37, 84%) studies reported significant increases in incidence and all (7 of 7) reported significant increases in prevalence. Data on the incidence and prevalence of VEO-IBD are limited to countries with historically high rates of IBD. Time trends in the incidence of VEO-IBD were visually heterogeneous. Conclusions
Rates of pediatric-onset IBD continue to rise around the world and data are emerging from regions where it was not previously reported; however, there remains a paucity of data on VEO-IBD and on pediatric IBD from developing and recently developed countries.
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