高价分子
试剂
化学
小学(天文学)
硅烷化
烷基
芳基
组合化学
模块化设计
胺气处理
有机化学
催化作用
计算机科学
天文
操作系统
物理
作者
Mingyan Ding,Ze-Xin Zhang,Thomas Q. Davies,Michael C. Willis
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-02-21
卷期号:24 (8): 1711-1715
被引量:20
标识
DOI:10.1021/acs.orglett.2c00347
摘要
A new N-silyl sulfinylamine reagent allows the rapid preparation of a broad range of (hetero)aryl, alkenyl, and alkyl primary sulfinamides, using Grignard, organolithium, or organozinc reagents to introduce the carbon fragment. Treatment of these primary sulfinamides with an amine in the presence of a hypervalent iodine reagent leads directly to NH-sulfonimidamides. This two-step sequence is straightforward to perform and provides a modular approach to sulfonimidamides, allowing ready variation of both reaction components, including primary and secondary amines.
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