肝癌
癌症
维生素
肝星状细胞
医学
激酶
生物
酪氨酸激酶
癌症研究
肝再生
肝硬化
信号转导
生物信息学
内科学
生物化学
细胞生物学
再生(生物学)
作者
Alemka Markotić,Tomislav Kelava,Helena Markotić,Hrvoje Silovski,Anna Mrzljak
标识
DOI:10.3325/cmj.2022.63.187
摘要
Vitamin D has been a focus of attention in liver cancer due to its direct and indirect antineoplastic effects. This review critically evaluates data from recently published basic and clinical studies investigating the role of vitamin D in liver cancer. Basic studies indicate that vitamin D plays an important role in liver cancer development by suppressing the activity of hepatic stellate cells and Kupffer cells. Furthermore, vitamin D has a direct anti-proliferative, anti-angiogenic, proapoptotic, and prodifferentiative effect on liver cancer cells. Recent investigation suggested several interesting mechanisms of these actions, such as inactivation of Notch signaling, p27 accumulation, and tyrosine-protein kinase Met/extracellular signal-regulated kinases inhibition. On the other hand, data from clinical observational studies, although promising, are still inconclusive. Unfortunately, studies on the effect of vitamin D supplementation were generally focused on short-term outcomes of chronic liver diseases (liver enzyme levels or elastographic finding); therefore, there are still no reliable data on the effect of vitamin D supplementation on liver cancer occurrence or survival.
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