相互作用体
生物
蛋白质-蛋白质相互作用
计算生物学
背景(考古学)
选择性拼接
功能(生物学)
遗传学
基因
信使核糖核酸
古生物学
作者
Jorge A. Holguin-Cruz,Leonard J. Foster,Jörg Gsponer
标识
DOI:10.1016/j.tcb.2022.04.004
摘要
Protein-protein interaction networks - interactomes - are charted with the hope to understand how phenotypes emerge and how they are altered in disease states. Early efforts to map interactomes have focused on the assembly of context agnostic, reference networks. However, recent studies have mapped interactomes across different cell lines and tissues, finding highly variable interactomes due to the rewiring of protein-protein interactions in different contexts. Increasing evidence points to significant links between protein structure and interactome diversity seen across cell types and tissues. We discuss how recent findings support the key role of alternative splicing and phosphorylation, two well-established regulators of protein structural and functional diversity, in defining cell type- and tissue-specific interactomes. Moreover, we show that intrinsically disordered protein regions are most favorably equipped to support interactome rewiring by acting as hubs of protein structure and function regulation.
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