纳米颗粒
动态光散射
壳聚糖
化学工程
傅里叶变换红外光谱
粒径
透射电子显微镜
核化学
溶解度
材料科学
化学
粒子(生态学)
高分子化学
纳米技术
有机化学
海洋学
地质学
工程类
作者
Hanjiu Chen,Jie Zhuang,Wu Xu,Xingliang Shen,Qianjie Zhang,Wanping Zhang
出处
期刊:Current Drug Delivery
[Bentham Science]
日期:2023-10-01
卷期号:20 (8): 1195-1205
被引量:2
标识
DOI:10.2174/1567201819666220513122319
摘要
The aim of this study was to encapsulate glabridin (GB) into nanoparticles, prepared by an ionic-gelation method blended with chitosan (CS) and poly-γ-glutamic acid (γ-PGA) to address the issue of poor stability and low water solubility of glabridin.The physicochemical properties of nanoparticles were investigated by transmission electron microscope (TEM), dynamic light scattering (DLS) and fourier-transform infrared (FT-IR) spectroscopy.FT-IR results indicated that the spontaneous interaction between CS, γ-PGA and GB can form a cross linked network-structure, leading to the spontaneous formation of nanoparticles. Morphology of the complex particles was nano-scale spherical shape. Furthermore, particle size was decreased according to the decrease of γ-PGA contents and CS, accompanying with the increase of mixed solution transmittance. The mγ-PGA : mGB = 1: 1 and mCS: (mγ-PGA + mGB) =1: 1 were considered to be a proper preparation condition of CS/γ-PGA/GB hybrid nanoparticles, which produced the smaller nanoparticles with the satisfactory encapsulation efficiency (EE), loading content (LC) and sustained GB release. With the increase of pH values, the potential, EE, and LC decreased gradually, while the particle size increased. The nanoparticles prepared with higher molecular weight γ-PGA had larger particle size and less loading capacity on GB. Additionally, moderate weight ratio of CS/γ-PGA/GB, low pH, and high molecular weight of γ-PGA were favorable for sustained release.It can be concluded that the physicochemical properties of nanoparticles and GB release behaviors were affected by several factors including the weight ratio of CS/γ-PGA/GB, pHvalues, and γ-PGA molecular weight (MW). Nanoencapsulation using CS, γ-PGA and GB has a potential application for the development of functional cosmetic products with skin-whitening effect.
科研通智能强力驱动
Strongly Powered by AbleSci AI