Recombinant factor VIIa for the management of severe hemorrhages in patients with hematologic malignancies.

Seven patients with hematologic malignancies were treated with recombinant activated factor VII (rFVIIa) for severe bleeding episodes complicating diagnostic procedures or high-dose chemotherapy associated or not with stem cell transplantation. All patients were thrombocytopenic and refractory to standard support. After administration of rFVIIa, 2 complete responses, 3 partial responses and 2 failures were documented.