Wnt信号通路
生物
爪蟾
信号转导
细胞生物学
遗传学
癌症研究
基因
作者
Renée van Amerongen,Martijn C. Nawijn,Jonathan Franca-Koh,John Zevenhoven,Hanneke van der Gulden,Jos Jonkers,Anton Berns
出处
期刊:Genes & Development
[Cold Spring Harbor Laboratory]
日期:2005-01-28
卷期号:19 (4): 425-430
被引量:66
摘要
Wnt-signal transduction through beta-catenin is thought to require the inhibition of GSK3 by Frat/GBP. To investigate the role of Frat in mammalian development, we have generated mice with targeted mutations in all three murine Frat homologs. We show that Frat is normally expressed at sites of active Wnt signaling. Surprisingly, Frat-deficient mice do not display gross abnormalities. Moreover, canonical Wnt signaling in primary cells is unaffected by the loss of Frat. These studies show that Frat is not an essential component of the canonical Wnt pathway in higher organisms, despite the strict requirement of Frat/GBP for maternal Wnt signaling in Xenopus.
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