蛋白质组学
计算生物学
化学
仿形(计算机编程)
生物化学
蛋白质化学
蛋白质组
酶
生物
计算机科学
基因
操作系统
作者
Benjamin F. Cravatt,Aaron Wright,John W. Kozarich
标识
DOI:10.1146/annurev.biochem.75.101304.124125
摘要
Genome sequencing projects have provided researchers with a complete inventory of the predicted proteins produced by eukaryotic and prokaryotic organisms. Assignment of functions to these proteins represents one of the principal challenges for the field of proteomics. Activity-based protein profiling (ABPP) has emerged as a powerful chemical proteomic strategy to characterize enzyme function directly in native biological systems on a global scale. Here, we review the basic technology of ABPP, the enzyme classes addressable by this method, and the biological discoveries attributable to its application.
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