In Vivo Antidiabetic Evaluation of Gymnema sylvestre Extract in Streptozotocin Induced

Gymnema sylvestre has been used medicinally throughout history by many different cultures. Many compounds have been found in the exudates of the Gymnema sylvestre plant that have been used medically by humans. We have examined the pharmacological hypoglycemic action of Gymnema sylvestre in diabetic rats. Gymnema sylvestre 100mg/kg (single dose study) reduced glucose, cholesterol, triglycerides, urea, creatinine, and lipids after treatment for 24 hrs. In chronic study (multiple dose study) also Gymnema sylvestre reduced creatinine, urea, lipids, triglycerides and glucose after 15days and significantly reduced glucose levels at 15th day in diabetic rats. In glucose tolerance test in diabetic rats with Gymnema sylvestre 100 mg/kg demonstrated glucose levels were found significantly less compared to the control group. Gymnema sylvestre serves as an important alternative source in the management of diabetes mellitus involved in reducing increased blood glucose during diabetes which should be examined further by oral hypoglycemic therapy.