AMPA受体
RNA编辑
兴奋性突触后电位
核糖核酸
神经科学
生物
细胞生物学
化学
生物物理学
NMDA受体
受体
生物化学
抑制性突触后电位
基因
作者
Hilda Lomelı́,Johannes Mosbacher,Thorsten Melcher,T. Höger,Jörg R. P. Geiger,Thomas Kuner,Hannah Monyer,Miyoko Higuchi,A. Bach,Peter H. Seeburg
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1994-12-09
卷期号:266 (5191): 1709-1713
被引量:715
标识
DOI:10.1126/science.7992055
摘要
AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor channels mediate the fast component of excitatory postsynaptic currents in the central nervous system. Site-selective nuclear RNA editing controls the calcium permeability of these channels, and RNA editing at a second site is shown here to affect the kinetic aspects of these channels in rat brain. In three of the four AMPA receptor subunits (GluR-B, -C, and -D), intronic elements determine a codon switch (AGA, arginine, to GGA, glycine) in the primary transcripts in a position termed the R/G site, which immediately precedes the alternatively spliced modules "flip" and "flop." The extent of editing at this site progresses with brain development in a manner specific for subunit and splice form, and edited channels possess faster recovery rates from desensitization.
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