医学
视网膜
视神经
视网膜中央动脉
血流
视网膜
眼动脉
血流动力学
颈内动脉
颈动脉疾病
眼科
灌注
视网膜动脉
心脏病学
狭窄
内科学
生物
神经科学
颈动脉内膜切除术
作者
Henning Heßler,Hanna Zimmermann,Timm Oberwahrenbrock,Ella Maria Kadas,Janine Mikolajczak,Alexander U. Brandt,Andreas Kauert,Friedemann Paul,Stephan J. Schreiber
摘要
Carotid artery disease (CAD) comprising high-grade internal carotid artery stenosis (CAS) or carotid artery occlusion (CAO) may lead to ipsilateral impaired cerebral blood flow and reduced retinal blood supply.To examine the influence of chronic CAD on retinal blood flow, retinal morphology, and visual function.Patients with unilateral CAS ≥ 50% (ECST criteria) or CAO were grouped according to the grade of the stenosis and to the flow direction of the ophthalmic artery (OA). Retinal perfusion was measured by transorbital duplex ultrasound, assessing central retinal artery (CRA) blood flow velocities. In addition, optic nerve and optic nerve sheath diameter were measured. Optical coherence tomography (OCT) was performed to study retinal morphology. Visual function was assessed using high- and low-contrast visual paradigms.Twenty-seven patients were enrolled. Eyes with CAS ≥ 80%/CAO and retrograde OA blood flow showed a significant reduction in CRA peak systolic velocity (no-CAD side: 0.130 ± 0.035 m/s, CAS/CAO side: 0.098 ± 0.028; p = 0.005; n = 12). OCT, optic nerve thicknesses, and visual functional parameters did not show a significant difference.Despite assessable hemodynamic effects, chronic high-grade CAD does not lead to gaugeable morphological or functional changes of the retina.
科研通智能强力驱动
Strongly Powered by AbleSci AI