肥胖
癌症
超重
子宫内膜癌
暴饮暴食
乳腺癌
腺癌
内科学
肾癌
肿瘤科
生物
医学
作者
Eugenia E. Calle,Michael J. Thun
出处
期刊:Oncogene
[Springer Nature]
日期:2004-08-23
卷期号:23 (38): 6365-6378
被引量:666
标识
DOI:10.1038/sj.onc.1207751
摘要
Large prospective studies show a significant association with obesity for several cancers, and the International Agency for Research on Cancer has classified the evidence of a causal link as 'sufficient' for cancers of the colon, female breast (postmenopausal), endometrium, kidney (renal cell), and esophagus (adenocarcinoma). These data, and the rising worldwide trend in obesity, suggest that overeating may be the largest avoidable cause of cancer in nonsmokers. Few obese people are successful in long-term weight reduction, and thus there is little direct evidence regarding the impact of weight reduction on cancer risk. If the correlation between obesity and cancer mortality is entirely causal, we estimate that overweight and obesity now account for one in seven of cancer deaths in men and one in five in women in the US.
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