Safe, efficient and selective synthesis of dinitro herbicidesvia a multifunctional continuous-flow microreactor: one-step dinitration with nitric acid as agent

A continuous and selective method for synthesis of dinitro herbicides through one-step dinitration approach has been successfully developed in microreactor systems. Compared to a conventional two-step batch process, reaction can be conducted without the need to separate intermediates and much less solvent or solvent-free condition has been employed.