肠动力
运动性
腺苷酸激酶
刺激
作用机理
分泌物
化学
环化酶
平滑肌
管腔(解剖学)
药理学
内科学
内分泌学
医学
细胞生物学
生物
生物化学
酶
体外
作者
Timothy S. Gaginella,Paul Bass
出处
期刊:Life Sciences
[Elsevier]
日期:1978-09-01
卷期号:23 (10): 1001-1009
被引量:95
标识
DOI:10.1016/0024-3205(78)90659-8
摘要
Laxatives, traditionally thought to act by stimulating intestinal motility, have other actions which result in laxation. They produce myoelectric alterations in intestinal smooth muscle and induce accumulation of luid in the intestinal lumen; these effects cause rapid transit of material through the bowel. Laxative-induced fluid accumulation may be brought about by inhibition of ion and water absorption, stimulation of fluid secretion, or both concomptantly. Inhibition of cellular energy production or utilization, mucosal injury and activation of adenylate cyclase may be involved in the mucosal action of these agents. The pharmacologic activity of laxatives involves both mucosal and muscle sites of action.
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