医学
单核苷酸多态性
基因型
等位基因
免疫学
狼疮性肾炎
优势比
次等位基因频率
基因型频率
等位基因频率
SNP公司
遗传倾向
遗传学
内科学
生物
疾病
基因
作者
F-R Chen,Z-F Zhai,X-W Shi,Lei Feng,Bincheng Zhong,Yan Wj,H Wang,Y Chen,Yi You,Na Luo,D-M Zhang,Hao Fei
出处
期刊:Lupus
[SAGE]
日期:2015-02-22
卷期号:24 (10): 1037-1044
被引量:7
标识
DOI:10.1177/0961203315571463
摘要
Studies in animal models have indicated that Pellino 1 is involved in inflammatory and autoimmune diseases, such as systemic lupus erythematosus (SLE). The current study was designed to determine whether PELI1 confers genetic susceptibility to SLE in humans, as assessed in a Chinese Han population.Blood samples were drawn from patients diagnosed with SLE and healthy volunteers. Three single nucleotide polymorphism (SNP) loci with a minor allele frequency of at least 0.05 were chosen to evaluate the correlation between PELI1 genotype and the incidence of SLE.There was a significant difference in the frequency distribution of the rs329497 allele between the SLE patients and the healthy controls (A vs. G; Bonferroni corrected p = 0.036, odds ratio = 0.75, 95% confidence interval = 0.60-0.94). No differences in the genotype and allele frequencies of other SNP loci were observed between the two groups. Furthermore, the alleles and genotypes of the three SNPs were not associated with lupus nephritis.In the Chinese Han population, PELI1 SNPs may be associated with SLE susceptibility.
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