免疫系统
癌细胞
钾
细胞外
生物
癌症
细胞生物学
程序性细胞死亡
癌症研究
细胞
流出
免疫学
化学
生物化学
细胞凋亡
遗传学
有机化学
作者
K. George Chandy,Raymond S. Norton
出处
期刊:Nature
[Springer Nature]
日期:2016-09-14
卷期号:537 (7621): 497-499
被引量:32
摘要
Potassium released from dying tumour cells has now been found to suppress the activity of T cells of the immune system. Enhancing the removal of potassium from T cells restores their ability to attack cancer. See Letter p.539 Cell death in tumours is frequently associated with a poor prognosis, a phenomenon that has previously been attributed to rapidly dividing cancer cells in a resource-limited environment. Robert Eil et al. demonstrate that intratumoural cell death in fact plays an active part in suppressing anti-tumour immunity. They show that elevated extracellular potassium in human and mouse tumour interstitial fluid inhibits T-cell-receptor-induced anti-tumour functions in human and mouse T cells. In addition, this immune suppression can be reversed by enabling tumour-specific T cells to efflux potassium through overexpression of the exporter Kcna3.
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