Synthesis of Benzoazepinone Derivatives via Photoredox Deaminative Radical Cascade Alkylation of 1,7-Dienes and 1,7-Enynes

Abstract A deaminative alkyl radical cascade cyclization of 1,7-dienes is described under visible-light photocatalysis. This method delivers a family of benzoazepinones (benzazepinones) and occurs under mild reaction conditions to access a broad substrate scope with excellent functional group tolerance and good yields. This protocol has also been extended to 1,7-enynes, furnishing a representative collection of cyclopentaquinolinones.