Medical Practice Questions: Transcutaneous Electrical Nerve Stimulation (TENS) and Percutaneous Electrical Nerve Stimulation (PENS) and Electroacutherapy.

PROPHYLACTIC COLCHICINE USE that colchicine therapy may prevent, reverse or impede the progression of amyloidosis.1416 At present, therefore, there is little question that those ethnic groups at high risk for amyloidosis developing should be receiving continuous colchicine therapy.Colchicine administration has been used with variable success in several other clinical disorders such as gout, pseudogout, Behget's disease, necrotizing vasculi- tis, scleroderma and Paget's disease, but little is known about its mechanism of action.Although interference with microtubule formation, degranulation of neutro- phils and alteration of leukocyte adenosine 3':5'-cyclic phosphate levels have been found in vitro, the relevance of these effects to colchicine prophylaxis for familial Mediterranean fever is unclear.'7"18