作者
Supinda Bunyavanich,Patrice M. Becker,Matthew C. Altman,Jessica Lasky‐Su,Carole Ober,Karsten Zengler,Evgeny Berdyshev,Richard Bonneau,Talal A. Chatila,Nilanjan Chatterjee,Kian Fan Chung,Colleen Cutcliffe,Wendy F. Davidson,Gang Dong,Gang Fang,Patricia C. Fulkerson,Blanca E. Himes,Liming Liang,Rasika A. Mathias,Shuji Ogino,Joseph F. Petrosino,Nathan D. Price,Eric E. Schadt,James Schofield,Max A. Seibold,Hanno Steen,Lisa M. Wheatley,Hongmei Zhang,Alkis Togias,Kohei Hasegawa
摘要
Abstract
Studies of asthma and allergy are generating increasing volumes of omics data for analysis and interpretation. The National Institute of Allergy and Infectious Diseases (NIAID) assembled a workshop comprised of investigators studying asthma and allergic diseases using omics approaches, omics investigators from outside the field, and NIAID medical and scientific officers to discuss the following areas in asthma and allergy research: genomics, epigenomics, transcriptomics, microbiomics, metabolomics, proteomics, lipidomics, integrative omics, systems biology, and causal inference. Current states-of-the art, present challenges, novel and emerging strategies, and priorities for progress were presented and discussed for each area. This workshop report summarizes the major points and conclusions from this NIAID workshop. As a group, the investigators underscored the imperatives for rigorous analytic frameworks, integration of different omics data types, cross-disciplinary interaction, strategies for overcoming current limitations, and the overarching goal to improve scientific understanding and care of asthma and allergic diseases.