Inside Back Cover: Boosting the Catalase‐Like Activity of SAzymes via Facile Tuning of the Distances between Neighboring Atoms in Single‐Iron Sites (Angew. Chem. Int. Ed. 9/2024)

The versatile mechano-assisted in-situ MOF capsulation strategy enabled facile access to neighboring M2-SAzyme (M=Fe, Ir, Pt), even up to 1000 grams scale. Typically, Fe2-SAzyme mimicked catalase to efficiently trap and decompose H2O2 into O2, via cooperative hydrogen-bonding induced end-bridge adsorption, featuring double activity and ~6 times catalase/peroxidase selectivity than those of random Fe1-SAzyme, H2O2 affinity similar as bioenzyme. The precise manipulation of neighboring atomic distance dramatically switched the activity of Fe-SAzymes from generating to scavenging ROS, as reported by Hongyu Chen, Hongbing Ji et al. in their Research Article (e202316779).