神经调节
微电极
材料科学
选择性
纳米技术
计算机科学
神经科学
生物物理学
生物系统
化学
刺激
电极
生物化学
生物
物理化学
催化作用
作者
Claudio Verardo,Leandro Julian Mele,L. Selmi,Pierpaolo Palestri
出处
期刊:Journal of Neural Engineering
[IOP Publishing]
日期:2024-03-01
卷期号:21 (2): 026002-026002
标识
DOI:10.1088/1741-2552/ad2581
摘要
Objective. The controlled delivery of potassium is an interesting neuromodulation modality, being potassium ions involved in shaping neuron excitability, synaptic transmission, network synchronization, and playing a key role in pathological conditions like epilepsy and spreading depression. Despite many successful examples of pre-clinical devices able to influence the extracellular potassium concentration, computational frameworks capturing the corresponding impact on neuronal activity are still missing.Approach. We present a finite-element model describing a PEDOT:PSS-coated microelectrode (herein, simplyionic actuator) able to release potassium and thus modulate the activity of a cortical neuron in anin-vitro-like setting. The dynamics of ions in the ionic actuator, the neural membrane, and the cellular fluids are solved self-consistently.Main results. We showcase the capability of the model to describe on a physical basis the modulation of the intrinsic excitability of the cell and of the synaptic transmission following the electro-ionic stimulation produced by the actuator. We consider three case studies for the ionic actuator with different levels of selectivity to potassium: ideal selectivity, no selectivity, and selectivity achieved by embedding ionophores in the polymer.Significance. This work is the first step toward a comprehensive computational framework aimed to investigate novel neuromodulation devices targeting specific ionic species, as well as to optimize their design and performance, in terms of the induced modulation of neural activity.
科研通智能强力驱动
Strongly Powered by AbleSci AI