Recent bio-applications of covalent organic framework-based nanomaterials

Appearing as a new class of functional organic materials, covalent organic frameworks (COFs) have aroused a huge wave of interest in versatile fields ever since they were first proposed in 2005. Thanks to but not limited to their ultralight weights, high surface areas, ordered channels, variable functional groups and well-defined crystal structures, the applications of COF-based biomaterials in the fields of drug loading and delivery, photodynamic therapy, photothermal therapy, bioimaging, etc. are comprehensively summarized and introduced. The existing challenges and future prospects for this emerging but hot research direction are also discussed. It is hoped that this review will serve as a guidance for future research on COFs as multifunctional bioplatforms.