医学
呼吸系统
危险系数
环境卫生
四分位数
比例危险模型
污染物
空气污染
队列研究
队列
置信区间
内科学
生物
生态学
作者
Zhi-Hao Li,Xiaomeng Wang,Dan Liao,Qian Zhang,Zi-Ting Chen,Cheng-Shen Qiu,Xian Tang,Hongmin Li,L B Du,Peidong Zhang,Dong Shen,Xiru Zhang,Jin Gao,Wen-Fang Zhong,Peiliang Chen,Qingmei Huang,Weiqi Song,Dan Liŭ,Chuan Li,Huan Chen,Mao Chen
标识
DOI:10.1016/j.ecoenv.2024.116176
摘要
Ambient air pollution is a major global health concern. Yet, no study has thoroughly assessed its link to respiratory mortality. Our research evaluated the combined and individual effects of air pollutants on respiratory mortality risks based on the UK Biobank. A total of 366,478 participants were studied. A Cox proportional hazards model was used to estimate the respiratory mortality risk from combined long-term exposure to five pollutants, summarized as a weighted air pollution score. During a median of 13.6 years of follow-up, 6113 deaths due to respiratory diseases were recorded. The hazard ratios (HRs) and 95% confidence intervals (95% CIs) of respiratory diseases were 2.64 (2.05-3.39), 1.62 (1.23-2.12), 2.06 (1.73-2.45), 1.20 (1.16-1.25), and 1.07 (1.05-1.08) per 10 μg/m3 increase in PM2.5, PM2.5-10, PM10, NO2, and NOx, respectively. The air pollution score showed a dose-response association with an elevated respiratory mortality risk. The highest versus lowest quartile air pollution score was linked to a 44% increase in respiratory mortality risk (HR 1.44, 95% CI: 1.33-1.57), with consistent findings in subgroup and sensitivity analyses. Long-term individual and joint air-pollutant exposure showed a dose-response association with an increased respiratory mortality risk, highlighting the importance of a comprehensive air-pollutant assessment to protect public health.
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