Antifungal activity of bamemacrolactine C against Talaromyces marneffei and its possible mechanisms of action

The findings suggest that BAC exhibits antifungal activity against T. marneffei, elucidating its multifaceted mechanism of action involving disruption of cell membranes' integrity and inhibition of intracellular enzyme activities, in which the modulation of ACLY in the TCA cycle may play an important role.