An injectable sodium-mangiferin homopolymeric hydrogel accelerated skin full-thickness wound healing in guinea pig model

In the treatment of joints, mucosa, and full-thickness wounds, traditional implant surgery presents not only inconvenience but also a significant risk of wound infection. Additionally, the pharmaceutical application of mangiferin(MGF) has been severely restricted due to its poor water solubility. In this study, we reported the synthesis and characterization of sodium-mangiferin (MGF-Na(S)) using the salt formation method. This novel compound exhibits a solubility of up to 80 mg/mL, which is remarkably 800 times higher than that of MGF. Subsequently, MGF-Na(S) was combined with water to synthesize an injectable sodium-mangiferin homopolymeric hydrogel (MGF-Na(HG)). The hydrogel was further characterized, and its wound-healing properties were investigated. The results indicated that MGF-Na(HG) effectively extends the residence time of therapeutic agents on the wound surface, thereby enhancing wound healing. Moreover, this hydrogel forms a protective gel layer that prevents exogenous bacterial reinfection, providing an optimal environment for wound healing. Furthermore, the hydrogel demonstrated excellent self-healing and injectable properties, highlighting its potential for managing postoperative wounds. The successful utilization of this injectable, self-healing, and antibacterial MGF-Na(HG) in wound healing offers a novel approach for the application of MGF.