Effective therapy with simvastatin compound ointment in palmoplantar keratoderma induced by lanosterol synthase (LSS) gene variants

In this study, palmoplantar keratosis in four patients with variants in the LSS gene showed various degrees of improvement after 4–16 weeks of therapy using simvastatin and cholesterol ointment, while keratosis in a patient with MBTPS2 variant displayed poor response.