Aging and frailty are associated with inflammatory endotypic shifts in patients with chronic rhinosinusitis

Key points Frailty and aging are associated with a shift toward non‐type 2 inflammation in chronic rhinosinusitis (CRS). Frailty‐related shifts in sinonasal inflammatory mediators may be linked to biological senescence. Understanding the role of aging and frailty in CRS may have important treatment implications.