声动力疗法
压电
金黄色葡萄球菌
生物相容性
材料科学
活性氧
超声波传感器
超声波
辐照
纳米技术
化学
医学
细菌
生物化学
生物
复合材料
物理
放射科
核物理学
冶金
遗传学
作者
Chaofeng Wang,Wenchan Sun,Yiming Xiang,S. L. Wu,Yufeng Zheng,Yu Zhang,Jie Shen,Lei Yang,Chunyong Liang,Xiangmei Liu
标识
DOI:10.1002/smsc.202300022
摘要
Bacterial infections are a serious public health issue that threatens the lives of patients because of their ability to induce other lethal complications without prompt treatment. Conventional antibiotic therapy can cause bacterial resistance and other adverse effects. It is highly desirable to develop effective and antibiotic‐independent therapeutic strategies to treat various kinds of bacterial infections. Herein, sonodynamic‐enhanced piezoelectric materials MoS 2 and Cu 2 Oheterostructure that responds to exogenous ultrasound (US) and generates reactive oxygen for Staphylococcus aureus elimination are developed. It is shown in the results that the polariton charge induced by piezoelectric MoS 2 nanosheets under US irradiation can accelerate the transfer of electric in Cu 2 O. Furthermore, US irradiation induces valence conversion from Cu(I) to Cu(II), which can accelerate glutathione oxidation significantly and destroy the bacterial antioxidant defense system. Hence, the as‐prepared piezoelectric‐enhanced sonosensitizer possesses a highly effective antibacterial efficacy of 99.85% against S. aureus under US irradiation for 20 min, with good biocompatibility. Herein, effective ultrasonic piezocatalytic therapy is offered through constructing heterogeneous interfaces with ultrasonic piezoelectric response.
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