PI3K/AKT/mTOR通路
蛋白激酶B
细胞生物学
鼻咽癌
癌症研究
生物
细胞生长
基因敲除
信号转导
化学
细胞凋亡
医学
生物化学
内科学
放射治疗
作者
Hong Ren,Jin Zhang,Xiaomei Zeng,Zhen Wang,P.-Q. Liu,Chenglin Kang,Shuqi Qiu,Xianhai Zeng,Peng Zhang
标识
DOI:10.1007/s12672-023-00721-3
摘要
Nasopharyngeal carcinoma (NPC) is a prevalent cancer in Southern China, North Africa, and Southeast Asia. The translocase of the outer membrane (TOM) 40 is a transporter of mitochondrial proteins, and is involved in ovarian cancer cell growth. However, its role in the progression of NPC is still unclear. We found that TOM40 levels were upregulated in NPC tissues and multiple NPC cell lines. In addition, high TOM40 expression in the tumor tissues was associated with poor overall survival and disease specific survival. TOM40 knockdown in the NPC cell lines inhibited their proliferation in vitro and in vivo. Furthermore, TOM40 silencing also increased intracellular production of reactive oxygen species (ROS) and decreased mitochondrial membrane potential (MMP). Mechanistically, the anti-tumor effects of TOM40 silencing were dependent on the inhibition of AKT/mTOR signaling and activation of p53 signaling. To summarize, TOM40 mediates NPC progression through ROS-mediated AKT/mTOR and p53 signaling. Our findings highlight the potential of TOM40 as a therapeutic target for NPC.
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