慢性咳嗽
医学
病态的
刺激
慢性疼痛
神经科学
重症监护医学
气道
麻醉
哮喘
病理
心理学
精神科
免疫学
作者
Jaclyn A. Smith,Imran Satia,Huda Badri,Paul Marsden
标识
DOI:10.1016/j.neulet.2022.136934
摘要
In recent years our understanding of the neurophysiological basis of cough has increased substantially. In conjunction, concepts around the drivers of chronic coughing in patients have also significantly evolved. Increasingly it is recognised that dysregulation of the neuronal pathways mediating cough play an important role in certain phenotypes of chronic cough and therefore pathological processes affecting the nervous system are likely to represent key endotypes in patients. Taking inspiration from the study of neuropathic pain, the term hypertussia has been employed to describe the phenomenon of abnormal excessive coughing in response to airway irritation and allotussia to describe coughing in response to stimuli not normally provoking cough. This review aims to summarise current clinical evidence supporting a role for the hyperexcitability of neuronal pathways contributing to chronic coughing and suggest how these might align with the clinical features observed in patients.
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