非酒精性脂肪肝
锡尔图因
脂肪肝
β氧化
西妥因1
细胞质
脂肪酸
医学
疾病
生物化学
内科学
化学
内分泌学
生物
酶
NAD+激酶
基因
下调和上调
标识
DOI:10.1016/j.tem.2022.10.004
摘要
Recently, Hou et al. shifted the research focus from the function of nuclear sirtuin (SIRT)6 to that of cytoplasmic SIRT6, which deacetylates and activates long-chain acyl-CoA synthase 5 (ACSL5). Their findings provide mechanistic insight into the role of cytoplasmic SIRT6 in fatty acid oxidation, acting as a therapeutic target for combating nonalcoholic fatty liver disease (NAFLD).
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