生物
胰岛素抵抗
脂肪组织
转录组
电池类型
胰岛素受体
胰岛素
祖细胞
细胞生物学
脂肪生成
干细胞
细胞
基因
遗传学
内分泌学
基因表达
作者
Peng Xu,Minghui Wang,Neeraj Kumar Sharma,Mary E. Comeau,Martin Wabitsch,Carl D. Langefeld,Mete Civelek,Bin Zhang,Swapan K. Das
出处
期刊:Cell systems
[Elsevier]
日期:2023-01-01
卷期号:14 (1): 41-57.e8
被引量:1
标识
DOI:10.1016/j.cels.2022.12.005
摘要
Our knowledge of the cell-type-specific mechanisms of insulin resistance remains limited. To dissect the cell-type-specific molecular signatures of insulin resistance, we performed a multiscale gene network analysis of adipose and muscle tissues in African and European ancestry populations. In adipose tissues, a comparative analysis revealed ethnically conserved cell-type signatures and two adipocyte subtype-enriched modules with opposite insulin sensitivity responses. The modules enriched for adipose stem and progenitor cells as well as immune cells showed negative correlations with insulin sensitivity. In muscle tissues, the modules enriched for stem cells and fibro-adipogenic progenitors responded to insulin sensitivity oppositely. The adipocyte and muscle fiber-enriched modules shared cellular-respiration-related genes but had tissue-specific rearrangements of gene regulations in response to insulin sensitivity. Integration of the gene co-expression and causal networks further pinpointed key drivers of insulin resistance. Together, this study revealed the cell-type-specific transcriptomic networks and signaling maps underlying insulin resistance in major glucose-responsive tissues. A record of this paper's transparent peer review process is included in the supplemental information.
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