Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation

(Cell Stem Cell 29, 1333–1345.e1–e6; September 1, 2022) In Figure 1B of the originally published version of this manuscript, the authors mistakenly indicated that IL-22 was not included in the culturing medium for optimal patterning. However, IL-22 was in fact included, as indicated correctly in the diagram in Figure 1A. The authors have now replaced the incorrect minus sign in the IL-22 row at the bottom of Figure 1B with a correct plus sign in both the article online and the image included below, and they apologize for the confusion.Figure 1Optimal culture of human intestinal organoids with multi-differentiation capacity (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formationHe et al.Cell Stem CellAugust 23, 2022In BriefGenerating a long-term organoid culture model that displays extensive budding and harbors all cell types of the human small intestine reveals mechanism of human Paneth cell differentiation by IL-22-mTOR signaling. Full-Text PDF Open Access