Inhibitors of the mTOR signaling pathway can play an important role in breast cancer immunopathogenesis

PI3K/AKT/mTOR通路 乳腺癌 癌症 mTOR抑制剂的发现与发展 信号转导 癌症研究 雷帕霉素的作用靶点 调节器 医学 生物 内科学 细胞生物学 生物化学 基因
作者
Suleiman Ibrahim Mohammad,Farag M. A. Altalbawy,Saade Abdalkareem Jasim,Renuka Jyothi S,Azfar Jamal,Mohammed M. Naiyer,Shriya Mahajan,Hitesh Kalra,Mohammed Abed Jawad,Ahmed Hussein Zwamel
出处
期刊:Cell Biology International [Wiley]
卷期号:48 (11): 1601-1611 被引量:2
标识
DOI:10.1002/cbin.12231
摘要

Abstract This study explores the critical role of inhibitors targeting the mammalian target of rapamycin (mTOR) signaling pathway in breast cancer research and treatment. The mTOR pathway, a central regulator of cellular processes, has been identified as a crucial factor in the development and progression of breast cancer. The essay explains the complex molecular mechanisms through which mTOR inhibitors, such as rapamycin and its analogs, exert their anticancer effects. These inhibitors can stop cell growth, proliferation, and survival in breast cancer cells by blocking critical signaling pathways within the mTOR pathway. Furthermore, the essay discusses the implications of using mTOR inhibitors as a comprehensive therapeutic strategy. It emphasizes the potential benefits of combining mTOR inhibitors with other treatment approaches to enhance the effectiveness of breast cancer treatment. The evolving landscape of breast cancer research underscores the significance of mTOR as a therapeutic target and highlights ongoing efforts to improve and optimize mTOR inhibitors for clinical use. In conclusion, the essay asserts that inhibitors of the mTOR signaling pathway offer a promising approach in the fight against breast cancer. These inhibitors provide a focused and effective intervention targeting specific dysregulations within the mTOR pathway. As research advances, the integration of mTOR inhibitors into customized combination therapies holds excellent potential for shaping a more effective and personalized approach to breast cancer treatment, ultimately leading to improved outcomes for individuals affected by this complex and diverse disease.
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