The role of gasotransmitter hydrogen sulfide in plant cadmium stress responses

Cadmium (Cd) is a toxic heavy metal that poses a significant risk to both plant growth and human health. To mitigate or lessen Cd toxicity, plants have evolved a wide range of sensing and defense strategies. The gasotransmitter hydrogen sulfide (H₂S) is involved in plant responses to Cd stress and exhibits a crucial role in modulating Cd tolerance through a well-orchestrated interaction with several signaling pathways. Here, we review potential experimental approaches to manipulate H₂S signals, concluding that research on another gasotransmitter, namely nitric oxide (NO), serves as a good model for research on H₂S. Additionally, we discuss potential strategies to leverage H₂S-reguated Cd tolerance to improve plant performance under Cd stress.