Multivariate Flexible Metal–Organic Frameworks and Covalent Organic Frameworks

Precise control of the void environment, achieved through multiple functional groups and enhanced by structural adaptations to guest molecules, stands at the forefront of scientific inquiry. Flexible multivariate open framework materials (OFMs), including covalent organic frameworks and metal-organic frameworks, meet these criteria and are expected to play a crucial role in gas storage and separation, pollutant removal, and catalysis. Nevertheless, there is a notable lack of critical evaluation of achievements in their chemistry and future prospects for their development or implementation. To provide a comprehensive historical context, the initial discussion explores into the realm of "classical" flexible OFMs, where their origin, various modes of flexibility, similarities to proteins, advanced tuning methods, and recent applications are explored. Subsequently, multivariate flexible materials, the methodologies involved in their synthesis, and horizons of their application are focussed. Furthermore, the reader to the concept of spatial distribution is introduced, providing a brief overview of the latest reports that have contributed to its elucidation. In summary, the critical review not only explores the landscape of multivariate flexible materials but also sheds light on the obstacles that the scientific community must overcome to fully unlock the potential of this fascinating field.