SERPINB6 Promotes Epithelial‐Mesenchymal Transition via PI3K/AKT/mTOR Signalling Pathway in Glioma

ABSTRACT Glioma is the most common and highly invasive type of brain cancer in the central nervous system, characterised by a low survival rate and poor prognosis. The role of SERPINB6 has been proven crucial in programmed necrosis and cancer progression. However, its role in glioma has not yet been clearly defined. This study utilised bioinformatics methods and in vitro and in vivo experiments to assess the expression, function and potential mechanisms of SERPINB6 in the development of glioma. Our study found that SERPINB6 plays a carcinogenic role in glioma, and its expression level is significantly negatively correlated with patient prognosis. The study also found that inhibiting SERPINB6 expression can hinder the epithelial‐mesenchymal transition (EMT) of glioma cells. Conversely, overexpression of SERPINB6 aggravated the occurrence of EMT. Particularly noteworthy is the mechanism of SERPINB6 in promoting EMT in glioma, which is achieved through the activation of the PI3K/AKT/mTOR signalling pathway. By activating the PI3K/AKT/mTOR pathway, SERPINB6 promotes EMT in glioma, demonstrating its great potential as a new target for glioma treatment.