Ventricular-arterial coupling derived from arterial velocity pulse index to global longitudinal strain ratio in hypertension

Abstract Objective Ventricular-arterial coupling (VAC) evaluates the relationship between the left ventricle (LV) and the arterial system. This study aimed to assess VAC using the ratio of arterial stiffness (arterial velocity pulse index [AVI]) to myocardial deformation (global longitudinal strain [GLS]) in hypertension, and to determine whether it is more closely associated with vascular and cardiac damage than the conventional arterial elastance/left ventricular elastance (Ea/Ees) index. Methods AVI, GLS, arterial elastance (Ea), left ventricular end-systolic elastance (Ees), left ventricular ejection fraction (LVEF), and markers of left ventricular diastolic function (E/A and E’) were measured by echocardiography in 141 healthy controls and 141 hypertensive subjects. Result AVI/GLS ratio was significantly lower in hypertensive individuals compared to controls (-0.77±0.29 vs. -0.66±0.28, p=0.001). A low AVI/GLS ratio was correlated with age (r=-0.450, p<0.05) and LVEF (r=0.243, p<0.05). Receiver operating characteristic (ROC) analysis demonstrated that the AVI/GLS ratio had higher sensitivity for predicting early cardiovascular changes in hypertensive patients, with an area under the curve (AUC) of 0.645 (95% CI [0.565; 0.681]). Conclusions Hypertension is associated with worse ventricular-arterial coupling (VAC) when expressed by the AVI/GLS ratio compared to normal conditions. The AVI/GLS ratio proved to be more effective than traditional indices (Ea/Ees) in detecting differences in cardiovascular function in hypertensive individuals. The role of the AVI/GLS ratio in various clinical settings requires further investigation.