theRNA: a curated knowledgebase of functional RNA therapeutics spanning diverse modalities and disease applications

Abstract RNA therapeutics are transforming precision medicine, yet a dedicated resource for validated agents has been lacking. Here, we introduce theRNA (https://therna.renlab.cn/), the first comprehensive database of 6860 experimentally validated RNA therapeutics targeting 1310 diseases in human or animal models. Curated from 11 126 peer-reviewed studies, theRNA focuses exclusively on functional therapeutic RNAs, including messenger RNA, small interfering RNA, microRNA, long noncoding RNA, circular RNA, short hairpin RNA, antisense oligonucleotides, aptamers, and CRISPR-related RNAs. Each entry provides extensive annotations on delivery modalities, efficacy readouts, and clinical potential. A user-friendly interface enables rapid searching and interactive exploration. As the first dedicated database for functional RNA therapeutics, theRNA aims to accelerate therapy development and deepen mechanistic understanding of disease and treatment.