化学
碳负离子
钯
催化作用
区域选择性
药物化学
配体(生物化学)
氢
有机化学
生物化学
受体
作者
Rina Muto,Kenji Nagata,Yoshiki Nakazumi,Kaho Nakamura,Satoshi Ueno
标识
DOI:10.1021/acs.orglett.3c00534
摘要
The Pd/PMe3-catalyzed allylation of 1-(cyanomethyl)naphthalenes with allyl acetates proved to be para- rather than α-regioselective. This reaction is thought to proceed through ligand attack of the para-carbon in the arenes, electronically enriched by a cyano-stabilized α-carbanion, to the (π-allyl)palladium and a 1,5-hydrogen shift of the para-hydrogen from the dearomatized intermediate.
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