IL-25–ILC2–IL-13 axis improves traumatic brain injury by mediating CXCL-10-dependent regulation of blood brain barrier integrity

IL-25 promotes BBB repair and enhances neurological recovery following TBI by inducing ILC2-derived IL-13, which suppresses CXCL-10 and endothelial pyroptosis. These findings identify IL-25 as a potential therapeutic target for mitigating BBB damage and improving outcomes after TBI.