Visible-Light-Driven C(sp 3 )–H Bond Carboxylation of Benzyl Amines with CO 2 for the Synthesis of α-Amino Acids

α-Amino acids are vital structural motifs in both bioactive compounds and synthetic building blocks. However, the photocatalytic synthesis of α-amino acids directly from C(sp³)-H bonds and CO₂ is a long-standing challenge. Here we report a visible-light-driven C(sp³)-H bond carboxylation of benzylamine with CO₂ to synthesize substituted arylglycines. This reaction has mild reaction conditions, good functional group tolerance, and a wide substrate scope. Mechanistic studies show that carbon radicals and carbon anions as the key intermediates may be generated through a consecutive photoinduced electron transfer process.