Membrane-disrupting antibacterial activity of Artocarpus lacucha bark extract: a mechanistic study through experimental and computational approaches

This integrative study demonstrates that the hexane extract of A. lacucha bark exhibits promising antibacterial action, and its putative mechanism could be direct membrane disruption, along with possible FabH inhibition, thereby validating its traditional use. The findings highlight the potential of A. lacucha as a promising source of natural antibacterial agents and underscore the importance of integrating ethnopharmacological knowledge with modern mechanistic insights to address the growing threat of antimicrobial resistance.